University of Tehran Press Journal of Veterinary Research 2008-2525 68 2 2013 06 22 The Effect of parenteral administration of Erythromycin on Immunoglobulin G absorption in neonatal calves The Effect of parenteral administration of Erythromycin on Immunoglobulin G absorption in neonatal calves 167 173 31964 10.22059/jvr.2013.31964 FA Mahdi Rasekh Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Zabol, Zabol- Iran Mohammad Reza Mokhber Dezfouli Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran- Iran Mohammad Nouri Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz- Iran Daryoush Saadati Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Zabol, Zabol- Iran Abbas Haji Akhondi Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Tehran, Tehran- Iran Hamid Tavanaeimanesh Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran- Iran Gholamreza Nikbakht Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran-Iran Journal Article 2012 10 16 BACKGROUND: Motilides mainly erythromycin have a great ability to increase abomasal emptying rate. OBJECTIVES: The aim of this study was to evaluate the effect of erythromycin as a prokinetic agent on abomasal emptying rate and Immunoglobulin G absorption in neonatal calves. METHODS: Twelve Holstein neonate calves were divided into two groups (treatment and control)of 6 Calves each.One hour after birth, treatment and control groups were injected by Erythromycine (8.8 mg/kg; IM) and normal saline (IM). After 30 minutes, calves were fed by 3 liters of colostrum using esophageal tube. Venous blood samples for determination of plasma IgG were obtained at 1, 3, 6, 9, 12, 18, 24, 36, 48 hours and 5 and 7 days after birth. RESULTS: The results showed that administration of erythromycin caused a significant increase in the serum IgG level (20.394 mg/mL), compared to the control group (15.021 mg/mL). CONCLUSIONS: This study revealed that erythromycin increases the serum IgG level probably through abomasal emptying acceleration. BACKGROUND: Motilides mainly erythromycin have a great ability to increase abomasal emptying rate. OBJECTIVES: The aim of this study was to evaluate the effect of erythromycin as a prokinetic agent on abomasal emptying rate and Immunoglobulin G absorption in neonatal calves. METHODS: Twelve Holstein neonate calves were divided into two groups (treatment and control)of 6 Calves each.One hour after birth, treatment and control groups were injected by Erythromycine (8.8 mg/kg; IM) and normal saline (IM). After 30 minutes, calves were fed by 3 liters of colostrum using esophageal tube. Venous blood samples for determination of plasma IgG were obtained at 1, 3, 6, 9, 12, 18, 24, 36, 48 hours and 5 and 7 days after birth. RESULTS: The results showed that administration of erythromycin caused a significant increase in the serum IgG level (20.394 mg/mL), compared to the control group (15.021 mg/mL). CONCLUSIONS: This study revealed that erythromycin increases the serum IgG level probably through abomasal emptying acceleration. https://jvr.ut.ac.ir/article_31964_edab7bb71df9ae7d13e729b3568a4ad1.pdf