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Objective: Study on antiapoptotic effect of Deprenyl in
sensory neurons of dorsal root ganglion of rat.
Animals: White Sprague-Dawley rats. The regions of
operation were sciatic nerve in midthigh and L dorsal root
ganglion.
Procedure: New born rats (3rd days) were divided into five groups and their left side sciatic nerves were
transected at midthigh region. Five test groups were
administered by deprenyl in different doses of: 0.1, 1, 10,
25 and50 mg/Kg and the antiapoptotic effect of drug were compared with control group.
Statistical analysis: The values obtained from each test
groups were compared with control group by t-test and
oneway ANOVA. Results: The results showed that treatment of animal with
deprenyl prevented reduction in neurons number, in dose
dependent manner.The group treated with dose 25mg/Kg
showed the better results.
Conclusion: Deprenyl is able to prevent the induction of
apoptosis in axotomized and nonaxotomized
neurons J.Fac. Vet.Med.Univ.Tehran. 60,1:65-69,2005