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Objective: To study the humoral immune - responses in sheep experimentally infected with 0. turkestanicum and
to compare two different antigens in E1ISA test: excretory
/secretory and somatic.
Design: Experimental study. Animals: Sixty sheep were divided into four groups : 1)
15 sheep were infected experimentally with 0.
turkestanicum, 2) 20 experimentally infected sheep with
Fasciola gicantica, 3) 20 experimentally infected sheep
with Echinococcus granulosus 4) 5 non infected lambs -
control groups.
Procedure: In this study total antibody response to worm
extract antigens and to excretory/ secretory products (ES) were determined in 15 Ornithobilharzia turkestanicum
infected sheep at monthly intervals for 12 months.
Results: The infection induced an early and relatively
highly immune-response to adult worm extract This response reached its maximum level at 4 months post
infection. The response to worm extracts antigens was
slighthly higher than to ES products . The response against
ES antigens was started later and remained at its maximum level untile 10 - 12 months after infection. A remarkable level of cross- reactivity was observed when Fasciola gigantica antisera were used .A low degree of cross
reactivity was found with ES antigens of 0 .
turkestanicum.There were not any cross reactivity between anti Echinoccucos granolusos sera to both tested
antigens (ES & worm extract). J.Fac. Vet.Med. Univ.
Tehran. 60,1:79-86,2005.