This study aimed to evaluate the effect of some anesthetic and preanesthetic drugs on intraocular pressure in dogs. The drugs or combination of drugs which used in this study were group 1; xylazine 2 mg/kg IM, group 2; acepromazine 1mg/kg IM, group 3;diazepam 1mg/kg IM, group 4; ketamine 30 mg/kg IM, group 5; sodium thiopental 25 mg/kg IV, group 6; combination of xylazine 3 mg/kg IM and sodium thiopental 20mg/kg IM and group 7; combination of acepromazine 0.1 mg/kg IM and sodium thiopental 20mg/kg IV. Intraocular pressure were measured
before and 5,10,15,30,60 and 90 minutes after injection and 2% tetracaine eye drops for local anesthetic of the eye and Schiotz tonometer. The data obtained in this study statistically analyzed with paired student “t” test and p value less than 0.05 was considered as the level of signigicant. The injection of xylazine cauesd significant reduction in intraocular pressure and continued till 90 minutes. Both acepromazine and diazepam caused 10 minutes reduction in intraocular pressure, but gradually increased afterl5 minutes. Injection of ketamin as an anesthetic alone caused high increase in intraocular pressure and maintained wit him 60 minutes. Maximum pressure was recorded at 30 minutes after injection, the injection of thiopental alone or combination of xylazine and ketamine caused no significant changes on intraocular pressure in tested dogs. Changes in intraocular pressure with the combination of acepromazine and thiopentone were significant within 30 minutes. the results of this study showed that xylazine, acepromazine and diazpam in clinical dosage decrease the intraocular pressure but ketamine increases the pressure, suggesting that it should be used with xylazine to prevent increase in intraocular pressure.
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