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Objective: Investigation of possibility and the role of?-
aminobutyric acid (GABA) in the fish pituitary functional
regulation ,by measuring the changes in blood serum GTH
levels. Design: Experimental study. Animals: Fifty sexually regressing female carps.
Procedure: Seven experimental conditions were
tested. Injection with just normal saline (control or basal)
and intraperitoneal injection of Bac.(9 mg/kg), LRH-A (50
ug/kg), Met.(15 mg/kg), Bac.+LRH-A, Met.+LRH-A, Bac.+ Met.+LRH-A were done. In this study fishes were
bled imediately before injection and 5 hours after then.
Statistical analysis: Pre and post-treatment GTH-I values were compared by t-test and Mann-Whithney U test. Results: Experiments indicated that only the injection of baclofen alone could produce a significant decrease in the
serum GTH-I levels. Other factors, whether alone or in
combination with each other did not produce acceptable
changes in GTH-I secretion at least in this stage of sexual
cycle.
Conclusion: The results of the present study suggest that
GABA may be one modulator for serum GTH-I levels in
the sexually regressing female carps.
J.Fac. Vet. Med.Univ.Tehran. 60,3:265-271,2005.