BACKGROUND: Immunostimulants play an important role in strengthening the immune system of fishes and prevention of various diseases. OBJECTIVES: This study was carried out to evaluate the effect of different levels of Immunoster (IS) and Immunowall (IW) immunostimulants on hematological, biochemical and immune indices in farmed juveniles great sturgeon (Huso huso) over 8 weeks. METHODS: After one month acclimatization period to rearing conditions and basal diet, 450 farmed juveniles great sturgeon (95.58 ± 9.38 g) were categorized as a completely randomized designing into five treatments (Control, IS 1%, IW 1%, IS 3% and IW 3%) in three replicates groups and kept at a density of 30 fish per tank. At the end of 8th week, blood samples were randomly collected (9 fish per treatment). RESULTS: The values of hematocrit, hemoglobin, mean corpuscular hemoglobin (MCH), mean corpuscular value (MCV), mean corpuscular hemoglobin concentration (MCHC), WBC, RBC, cell differentiation, total protein, albumin, IgM and lysozyme were determined. Hematocrit, hemoglobin (except IS 1%), WBC (except IW 3%), MCH, MCV (p<0.05) and percent of neutrophil showed an increase in both immunostimulant treated groups compared the control one. Meanwhile the maximum lymphocyte count was seen in IW 3%. It was also observed an increase in total protein, albumin (except IS 3%) and lysozyme concentrations of the treated groups compared the control one. CONCLUSIONS: It can be concluded that Immunoster and Immunowall can improve hematological, biochemical and immune indices in juvenile farmed great sturgeons.