The effects of lntracerebroventricular (I.C.V) administration of PGE2, PGF2a and Indomethacin on feeding behavior were examined in conscious rabbits, which were chronically prepared with a cannula in cerebral lateral ventricle. The drugs had dose-dependency short and long-term effects to decrease food intake but PGF2a at doses of 12.5, 75, 125pg was considerably less potent than PGE2 (12, 17, 25pg) and hypophagia occurred only occasionally in lower doses. It is concluded that PGs may have anorectic properties. We suggest that PGs antagonize norepiriephrine (NE) effects on brain and they may be antagonistic to indogenous NE transmitter in the medial and lateral hypothalamus and also depress calcium Ions up take and may alter neural calcium fluxes which cause anorexia Intramuscular Injection of indomethacin in order to inhibit the indogenous PG causes to increase in food intake.
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