Effects of insulin (1, 2 and 3 IU/kg, i.p.), morphine (5mg/kg, i.p.), naloxone (5mg/kg, s.c.), insulin before morphine and after naloxone were studied in the formalin test of mice. Formalin test was induced by intraplantar injection of formalin (20m, 5%). Morphine alone and insulin with morphine decreased the first phase (0-5 min) of pain. Naloxone increased the interphase (6-20 min) of niciception. Insulin and morphine decreased the second phase (21-40 min) of pain. Insulin enhanced the morphine - induced antinociception. Naloxone attenuated the suppressive effect of insulin. It seems that the antinociceptive effect of insulin in the formalin test may be dependent on the activation of opioid system.
Tamaddonfard, E., Goli, M., & Seidnejhad, S. (2008). INTERACTION BETWEEN INSULIN AND OPIOID SYSTEM IN THE FORMALIN TEST OF MICE. Journal of Veterinary Research, 63(4), 291-295.
MLA
Esmaeel Tamaddonfard; Mojtaba Goli; Sona Seidnejhad. "INTERACTION BETWEEN INSULIN AND OPIOID SYSTEM IN THE FORMALIN TEST OF MICE", Journal of Veterinary Research, 63, 4, 2008, 291-295.
HARVARD
Tamaddonfard, E., Goli, M., Seidnejhad, S. (2008). 'INTERACTION BETWEEN INSULIN AND OPIOID SYSTEM IN THE FORMALIN TEST OF MICE', Journal of Veterinary Research, 63(4), pp. 291-295.
VANCOUVER
Tamaddonfard, E., Goli, M., Seidnejhad, S. INTERACTION BETWEEN INSULIN AND OPIOID SYSTEM IN THE FORMALIN TEST OF MICE. Journal of Veterinary Research, 2008; 63(4): 291-295.
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