Effects of intra-articular injection of iscoflupredone acetate on cellular and biochemical parameters of blood and synovial fluid in the horse

To evaluate the effects of intra-articular injection of isoflupredone
acetate on blood and synovial fluid (SF) parameters, five crossbred
horses were tested. Blood and SF samples were collected before
the administration of isoflupredone acetate as control values.
Following the injecticm of isoflupredone acetate (10mg) into the SF
of the right intercarpal joint, blood and SF samples were obtained
from the horses at 4, 9 and 14 days for cellular, physical and
biochemical tests. Following the injection of isoflupredone acetate,
viscosity and mucin clot were slightly decreased, however color and
transparency of SF were not affected. The number of WBCs in SF
were significantly (p<0.05) increased, while, the number of RBCs,
were significantly decreased (p<0.0 1). The f:oncentration of
inorganic phosphorous, potassium, and the activity of AST and
ALP in synovial fluid significantly increased (p<0.0l) following the
intra-articular injection of isoflupredone acetate. The number of
WBCs and RBCs, percentage of eosinophUs and mono cytes in
blood and the concentration of glucose, calcium and inorganic
phosphorus were significantly changed in serum (p<0.05). The
number of eosinophils and the concentration of glucose
significantly (p calcium and inorganic phosphorus significantly (p