Seroepidemiological study of Helicobacter pylori in related and non-related people with dogs and cats in Ahvaz (2014-2015)

Authors

1 Graduated from Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2 Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

3 Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

4 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

5 Department of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

BACKGROUND: Helicobacter pylori is one of the most common bacterial infections in humans that is associated with Gastric and duodenal ulcers, gastritis and gastric cancer. Helicobacter pylori is transmitted through food and water and fecal-oral and oral-oral routes and colonized in the stomach and intestines of humans and several animal species including dogs and cats, and therefore the possibility of transmission of infection from animals to humans exists. OBJECTIVES: The aim of this study was to determine the seroprevalence of Helicobacter pylori infection in humans, related and unrelated to dogs and cats in Ahvaz, as well as its relationship with host and environmental factors. METHODS: Serum samples were collected from 356 volunteers, including 147 related and 209 unrelated individuals with  dogs and cats and evaluated by ELISA. RESULTS: Apparent and real seroprevalence of Helicobacter pylori infection were 58.4% (95% CI: 53.3 – 63.3 percent) and 44.53% (95% CI: 39.33 – 49.73 percent), respectively. The apparent prevalence in related and unrelated individuals with the dogs and cats were 72.1% (95% CI: 64.8-79.4 percent) and 48.8% (95% CI: 42-55.6 percent), respectively (p<0.001). The risk of infection in related individuals compared with unrelated was 2.71 (95% CI: 1.73 – 4.26) (p<0.001). This study showed that exposure to cats and dogs, education, history of gastric ulcers and gastrointestinal disorders and marital status are significantly correlated with infection. CONCLUSIONS: The present study showed that contact with dogs and cats can be a risk factor for Helicobacter pylori infection in humans and preventive and control measures should be considered by health authorities.

Keywords

References

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