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Salmonella infections in human and animals is one of the most important disease around the world. In the genus of Salmonella, Salmonella enteric a subsp enteric a serovar Typhimurium has special situation, because of it’s broad host range and wide geographical distribution. In present study all attempt was done to develop a potent effective vaccine against Salmonellosis. So the immunogenicity effects of heated (70C, 30 mm) and formalized (0.1%) vaccine of S. typhimurium were evaluated in rabbits. Two groups of rabbits (groups F&H) were vaccinated with inactivated vaccines several times via s.c and im. In the different period steps between of vaccination times, the immune response were assayed by agglutination (Widal test) test. The results indicated that the inactivated vaccines induced a highly level of antibodies and also protective