Beta- aminopropionitril fumarat (BAPN-f) is evaluated as a scar remodeling drug. and can inhibit HP cross-linking between collagen bundles by enzyme block. There is no report on affecting BAPN-f on molecular composition of flexor tendon in horses, but a few clinical trail was report the good effects of BAPN-f on acute and sub acute tendonitis in horses. In this study the effect of BAPN-f
(09 mg/ml) on molecular composition of experimental injured flexor tendon in horses was compared with physiologic normal salin (0.9% NaCl). Eight aparently healthy horse& (Age mean 7 years and weight mean 320kg) were used. Under general an aesthesia Zig-Zag splitting was performed on DDF-T on one forelimb of all horses, the horses divided into two groups and recived BAPN-f 0.9mg/ml and NaCl 0.9% respectively, by injection into the site of injury every other days for five successive days. Sixthy days after last injection horses were euthanatized and samples were taken for biochemistry evaluations In biochemistry evaluation there was no statistical differences between DNA content in two groups (P<0.05). PSGAGs and collagen content were significantly increased in BAPN-f group (P<0.05). HP cross linking in BAPN-f group was significantly decress to compare NaC1 group (P<0.05). Therefore, intralesional injection of BAPN-f 0.9 mg/ml can improved healing significantly in this model of tendonitis by inhibit HP cross linking in early stage of healing.
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