Journal of Veterinary Research

Journal of Veterinary Research

COMPARATIVE STUDY ON 1D (VP1) REGION OF FOOT AND MOUTH DISEASE VIRUS (TYPE A STRAIN) AMONG DIFFERENT ISOLATES: KHORASAN RAZAVI ISOLATE AND OTHER IRANIAN AND NEIGHBORING COUNTRIES ISOLATES

Authors
Saied Zibaei
Hadi Keivanfar
Mohammad Rabbani
Farhid Hematzadeh
Mehdi Kianizade
Mohsen Fathi najafi
Majid Farhodi
Mohammad Hemmati
Abstract
Foot -and- mouth disease (FMD) is one of the most important virus disease in farm animals. Types O, A and Asia1 FMD virus have been endemic in Iran. In these study, samples from suspected livestock were analyzed by RT-PCR experiment. The number of 702 nucleotides determined at 1D -2B region of type A strain isolated from Khorasan Razavi province sequenced and compared with that of other reported isolates type A from Iran and neighboring countries.The results show that field isolated type A has about 89% similarity with other reported isolates type A from Iran and neighboring countries. Furthermore, this virus shows the most similarity with A/IRN/1/87(Samuel). Phylogenitic analysis revealed that virus was closely related to A22-Iraq/99 and A/IRN/iso/105 that rest in the same lineage. The data showed high similarity between type A viruses involved in the Khorasan Razavi province and A/IRN/87v (vaccine strain); so that it can be concluded that the vaccine can produce prophylactic antibody against this virus.
Keywords
foot and mouth disease virus
khorasan- razavi province
type A