COMPARATIVE STUDY ON 1D (VP1) REGION OF FOOT AND MOUTH DISEASE VIRUS (TYPE A STRAIN) AMONG DIFFERENT ISOLATES: KHORASAN RAZAVI ISOLATE AND OTHER IRANIAN AND NEIGHBORING COUNTRIES ISOLATES

Zibaei, Saied; Keivanfar, Hadi; Rabbani, Mohammad; Hematzadeh, Farhid; Kianizade, Mehdi; Fathi Najafi, Mohsen; Farhodi, Majid; Hemmati, Mohammad

COMPARATIVE STUDY ON 1D (VP1) REGION OF FOOT AND MOUTH DISEASE VIRUS (TYPE A STRAIN) AMONG DIFFERENT ISOLATES: KHORASAN RAZAVI ISOLATE AND OTHER IRANIAN AND NEIGHBORING COUNTRIES ISOLATES

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Abstract

Foot -and- mouth disease (FMD) is one of the most important virus disease in farm animals. Types O, A and Asia1 FMD virus have been endemic in Iran. In these study, samples from suspected livestock were analyzed by RT-PCR experiment. The number of 702 nucleotides determined at 1D -2B region of type A strain isolated from Khorasan Razavi province sequenced and compared with that of other reported isolates type A from Iran and neighboring countries.The results show that field isolated type A has about 89% similarity with other reported isolates type A from Iran and neighboring countries. Furthermore, this virus shows the most similarity with A/IRN/1/87(Samuel). Phylogenitic analysis revealed that virus was closely related to A22-Iraq/99 and A/IRN/iso/105 that rest in the same lineage. The data showed high similarity between type A viruses involved in the Khorasan Razavi province and A/IRN/87v (vaccine strain); so that it can be concluded that the vaccine can produce prophylactic antibody against this virus.

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