THE COMPARISON OF STANDARD HEPARIN AND DALTEPARIN ON PREVENTION OF ADHESION IN PERITONITIS WITH OR WITHOUT INFECTION IN RAT

Pourjafar, Mehrdad; کریمی, Iraj; Farid, Mahdi; Maghsoudi, Ehsan; Shakhse Nieaee, Mostafa

THE COMPARISON OF STANDARD HEPARIN AND DALTEPARIN ON PREVENTION OF ADHESION IN PERITONITIS WITH OR WITHOUT INFECTION IN RAT

Authors

Mehrdad Pourjafar

Iraj کریمی

Mahdi Farid

Ehsan Maghsoudi

Mostafa Shakhse Nieaee

Abstract

In our experimental study, 48 rats were divided into six groups in a randomized manner: A (1-3) and B (1-3) groups. A1 and B1 were negative controls. Laparotomy was performed and peritoneal inflammation on exposed bowel and peritoneum in A (1-3) and experimental infection induced in peritoneal cavity of B (1-3). Each rat of A2 and B2 received 100 IU intraperitoneal standard heparin and each rat of A3 and B3 received 100 IU intraperitoneal dalteparin. On the 21st postoperative day, rats were euthanized and intensity of intraperitoneal adhesions evaluated macroscopically. The results were analyzed with Chi-Square test. Peritoneal adhesions in experimental groups reduced significantly(p<0.05) in comparison with controls, but nosignificant differences were seen between experimental groups(p>0.05). So, dalteparin and standard heparin are effective in preventing adhesion in infectious and noninfectious peritonitis but nosignificant differences were found between these drugs (p>0.05). In brief, regarding to the in vivo beneficial effects of LMWH, dalteparin is more recommended.

Keywords

Heparin

infectious peritonitis

low molecular heparin

peritoneal adhesion

rat