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Objective: Comparison of the protective effects of ranitidine with sucralfate against aspirin induced gastric mucosal lesions in dog.
Design: Experimental study Animals: eighteen healthy mongrel dogs.
Procedure: Eighteen dogs were divided into four groups:
group l)aspirin 25 mg/kg every 12 hours. Group 2)aspirin with the above dose and ranitidine 150 mg/dog every 12 hours. Group3) aspirin with the above dose and sucralfate 1000 mg/dog every 1 2 hours. Group 4) no medication. Weekly endoscopic examination
was performed on all of the dogs and observed gastric lesions were
graded. At the end of 8th week, the animals were both sacrifificed and their stomachs and duodenums were evaluated macroscopically and microscopically.
Stalistial analysis: Kruskall wallis, manrwithney and sign tests.
Results: Group 2 had lesser mean gastric lesion scores compared
with group I in the first and third weeks. Group 2 had milder lesions with group 3 meaningfully only in the first week of study.
Conclusion: Ranitidine is effective as a protective measure against gastric lesions induced by short term use of aspirin . But sucral fate is not effective neither in short term, nor in long term following
use of aspirin.