In this research 10 rabbits were used in two groups of control and treatment. Chronic treatment of isoprenaline with dosage of 8.5mg/kg for 22 days revealed remarkable changes in rabbit parotid gland. Such as causing of increasing the weight of parotid gland. In the histological studies hyperplasia and hypertrophy of secretion units with the increasing of mucopolysacharide materials were also reasonable. In the special staining the parotid gland was respond to the periodic acid shiff staining but not to alcian blue. At electron microscope level the presence of light secretion granules after treatment instead of dark granules before treatment in acinar secretory cells were determined.