Congenital cardiac defects in calves are uncommon, Although constitute a significant proportion of all bovine congenital defects. Two female Holstein calves 5 and 10 days olds were referred to the large Animal clinic, Faculty of Veterinary Medicine Tehran University at a period of 14 month. In clinical examination and Tachypnee were diagnosed in both cases, however one cases had developed pneumonia. Electro cardio- graphy and Echocardiography were taken. Both cases were subjected to postmortem examination. The calves showed ectopia cord is cervical is. There were different variations in the large vessels of the heart. One of them showed Patent Duct us Arteriosus and Patent Foramen ovale. All the observed defects on the septum and valves of the heart were documented.