Objective: The radiographic, ultrasonographic, hamatologic, biochemical and histopathologic studies were done the following routine ileocystoplasty in dogs.
Design: Experimental study.
Animals: Twelve female mixed-breed Persian dogs.
Procedure: Persian mixed breed female dogs between 1-2 year-old and 15-24 kg body-weight were divided into control and experiment groups. Routine ileocystoplasty was performed on experimental dogs. Twenty centimeters of ileal segments were detubulized to U-form and were grafted to bladder after performing the partial supratrigonal cystectomy. Radiography, ultrasonography, hematologic and biochemical evaluations were prepared on days 0, 14 and 35 from all animals. Experimental group animals also were euthanized on day 35. Neobladders were resected and histopathologic sections were taken.
Results: No radiographic changes were detected in plain and contrast radiography indicative of any leakage from
anastomotic and suture lines. Vesicoureteral reflux, ... was not present. Ultrasonography revealed neobladder walls thickened at the anastomotic site. No significant changes were found in hematologic parameters ,glucose, cholestrol, triglyceride, creatinine, total protein, albumine, glutamine, serum electrolytes (calcium, potassium, phosphorus, sodium, chloride and bicarbonate), albumin, pH, venous blood gases (Po2 and Pco2) and anion gap. BUN was found significantly higher in experiment group in comparison to control group.
There were not marked morphologic changes in ileal
mucosa, uroepithelial migrated from remaining portion of the bladder to cover the ileal segments. Inflammatory cells infiltrations were not significant in neobladders.
Clinical implications: Based on the study, ileal segment is useful source for graft the bladder in dog. J.Fac. Vet.Med. Univ. Tehran. 60,2:187-194,2005.