Enzootic calf bronchopneumonia is a multyfactorial disease that occurs in association whit the in telaction of various infectious agenes, and colf susceptibility. The economic losses is associated with death loss and treatment costs, reduction of live weight gain and reduced of productive life span, whith mey be considevable. The aim of this study was to examine the acute phase response in calves with enzootic pneumonia. We measured acute phase proteins (App) and identified some potential markers useful for evaluation of calve's health status. Sixty Holstein calves within two weeks to six months old were divided into two groups. Clinical findings of individual were recorded after the physical examination. Blood samples were taken from the calves and were used for Complete blood count (CBC) and serum biochemical evaluation. Clinical findings including body temperature, pulsation, and respiratory rate were significant between two groups. Hematological parameters showed no significant differences between two groups as well as some biochemical profiles (albumin and globulin). The results of this study indicated a significant increase in Haptoglobin (Hp) and Fibrinogen (p<0.05). Our results showed the application of Haptoglobin and fibrinogen measurements as indicators of health in calf herds, thereby facilitating treatment decisions.