The effect of Omeprazole on colostral total IgG absorption in neonatal lambs

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Abstract

BACKGROUND: Omeprazole as an inhibitor decreases abomasal acid secretion. On the other hand, acidity would be a determinant for absorption of Immunoglobulins. OBJECTIVES: The aim of this study was to evaluate the effect of increasing abomasal pH due to Omeprazole administration on the rate of intestinal immunoglobulin absorption in newborn lambs. METHODS: 30 lambs immediately after birth were divided into 6 groups of 5 animals each as follows: Group1; The lambs received colostrum from birth to 84 hours after birth. Group2; The lambs were fed by colostrum + Omeprazole (4mg/Kg) from birth to 84 hours after birth. Group 3; The lambs were given milk for the first 24 hours and after then until hour of 84 by colostrum + Omeprazole. Group 4; The lambs were fed with milk + Omeprazole for the first 24 hours and after then until hour of 84 with colostrum + Omeprazole. Group 5; The lambs received milk for the first 6 hours after birth and after then received colostrums until hour of 84. Group 6; The lambs were fed with milk + Omeprazole in the first 6 hours after birth and after then until hour of 84 by colostrum + Omeprazole. Blood samples were collected at 0,24,48,72 and 96 hours after birth. The total IgG was measured by ELISA method. RESULTS: Serum IgG levels in group 4 showed significant decrease when compared with the control (group 3). However, no significant difference was shown in the serum IgG levels among groups. CONCLUSIONS: The results of this study showed that after birth increase in abomasal pH do not make effect on IgG absorption.

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Journal of Veterinary Research
Volume 67, Issue 4 - Serial Number 4
December 2012
Pages 365-372

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