The Effect of parenteral administration of Erythromycin on Immunoglobulin G absorption in neonatal calves

Authors

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Zabol, Zabol- Iran

2 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran- Iran

3 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz- Iran

4 Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Zabol, Zabol- Iran

5 Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Tehran, Tehran- Iran

6 Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran-Iran

Abstract

BACKGROUND: Motilides mainly erythromycin have a great ability to increase abomasal emptying rate. OBJECTIVES: The aim of this study was to evaluate the effect of erythromycin as a prokinetic agent on abomasal emptying rate and Immunoglobulin G absorption in neonatal calves. METHODS: Twelve Holstein neonate calves were divided into two groups (treatment and control)of 6 Calves each.One hour after birth, treatment and control groups were injected by Erythromycine (8.8 mg/kg; IM) and normal saline (IM). After 30 minutes, calves were fed by 3 liters of colostrum using esophageal tube. Venous blood samples for determination of plasma IgG were obtained at 1, 3, 6, 9, 12, 18, 24, 36, 48 hours and 5 and 7 days after birth. RESULTS: The results showed that administration of erythromycin caused a significant increase in the serum IgG level (20.394 mg/mL), compared to the control group (15.021 mg/mL). CONCLUSIONS: This study revealed that erythromycin increases the serum IgG level probably through abomasal emptying acceleration.

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