Changes in clinical signs after treatment in calves with experimental colisepticemia with Escherichia coli


1 Department of Internal Medicine, Faculty of Veterinary Medicine University of Tehran, Tehran, Iran

2 Associated professor of Department of Clinical Sciences, Faculty of Veterinary Medicine University of Tehran, Tehran-Iran

3 Department of Dignostic Microbiology, Iran Veterinary Organization, Central Veterinary Laboratory, Tehran, Iran

4 Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

5 Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

6 Research & Production Complex Institute of Pasteur, Tehran, Iran

7 Graduated from the Faculty of Veterinary Medicine University of Tehran, Tehran, Iran


Background: Colisepticemia is an acute fatal disease in farm animal neonates. Clinical finding of septicemia is non-specific and cannot be differentiate from signs of non-infectious disease or disease with local infection such as diarrhea. Object: Evaluation of clinical signs variations in calves with experimental septicemia with Escherichia coli O111:H8. Methods: Colisepticemia were experimentally induced in ten Holstein bull calves after an adaptation period. Vital signs and 7 clinical criteria were recorded from 24h before septicemia until 48h after that. Blood culture was performed and treatment was done based on antibiogram from 24h after challenge. Results: Changes of suckling reflex and shock were not significant. Changes of appetite, dehydration, behavior, standing ability, total score from 24h before the challenge to 24h after treatment were significant(P


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