Diarrhea due to Candida famata in a dairy cattle herd located in the Varamin city.


1 Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

2 Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran


Background: Candidiasis is a fungal infection that is often caused by Candida albicans (C. albicans) and in a few cases caused by other Candida species. Infection of gastrointestinal tracts including mouth, esophagus and stomach, as well as enteritis and diarrhea are the most common form of the disease in cattle. Clinical findings: In January 2015 reduction in milk production and severe watery diarrhea were observed in a dairy farm located in Varamin city Tehran, Iran. So that 57.1% of cows with high milk production efficiency and 40% of cows with low milk production efficiency involved severe watery diarrhea. Laboratory tests: in clinical examination of affected animals vital signs such as number of breathing, heart rate, as well as the quality and number of ruminal movements were quite normal. No unusual sings were seen in CBC pattern of affected animals. In stool samples of affected animals no viruses or bacteria were detected while specimens were positive for yeast contamination RapID commercial kits used to identify the genus and species of yeast and C. famata was diagnosed as the cause of diarrhea. Final evaluation: Reports of diarrhea caused by fungal pathogens in animals is very low and Candida species, especially C. albicans and C. glabrata are known as the main causes of fungal diarrhea in animals .This study is the first repot about occurrence of C. famata diarrhea in adult cattle. So that C.famata could be considered as one of the potential causes of diarrhea in cattle.


Azimpour, S., Pourtaghi, H. (2016). A Case Report of Fungal Diarrhea in a Preweaned Calf in Iran. Int J Enteric Pathog. 4: 1-4.##
Beyda, N. D., Chuang, S. H., Alam, M. J., Shah, D. N., Ng, T. M., McCaskey, L., Garey, K. W. (2012) Treatment of Candida famata bloodstream infections: case series and review of the literature. J Antimicrob Chemother. 21: 388-391.##
Blanchard, P. C. (2012). Diagnostics of dairy and beef cattle diarrhea. Vet Clin North Am Small Anim Pract. 28: 443-464.##
Desnos-Ollivier, M., Ragon, M., Robert, V., Raoux, D., Gantier, J. C., Dromer, F. (2008). Debaryomyces hansenii (Candida famata), a rare human fungal pathogen often misidentified as Pichia guilliermondii (Candida guilliermondii). J Clin Microbiol. 46: 3237-3242.##
Elad, D., Brenner, J., Markovics, A., Yakobson, B., Shlomovitz, S., Basan, J. (1998) Yeasts in the gastrointestinal tract of preweaned calves and possible involvement of Candida glabrata in neonatal calf diarrhea.Mycopathologia. 141: 7-14.##
Elad, D., Brenner, J., Markovitcs, A., Shlomovitz, S., Basan, J., Schwartz, N. (2002). Influence of diet on the shedding of Candida glabrata by experimentally infected preweaned calves. Vet J. 164: 275-279.##
Izzo, M. M., Kirkland, P. D., Mohler, V. L., Perkins, N. R., Gunn, A. A., House, J. K. (2011). Prevalence of major enteric pathogens in Australian dairy calves with diarrhoea. Aust Vet J. 89: 167-173.##
Kawakami, S. I., Yamada, T., Nakanishi, N., Cai, Y. (2010) Feeding of lactic acid bacteria and yeast on growth and diarrhea of Holstein calves. J Anim Vet Adv. 9: 1112-1114.##
Krause, R., Schwab, E., Bachhiesl, D., Daxböck, F., Wenisch, C., Krejs, G. J., Reisinger, E. C. (2001). Role of Candida in antibiotic-associated diarrhea. J Infect Dis. 184: 1065-1069.##
Milner, R. J., Picard, J., Tustin, R. (1997). Chronic episodic diarrhoea associated with apparent intestinal colonisation by the yeasts Saccharomyces cerevisiae and Candida famata in a German shepherd dog: case report. J S Afr Vet Assoc. 68: 147-149.##
Oberoi, J. K., Wattal, C., Goel, N., Raveendran, R., Datta, S., Prasad, K. (2012). Non-albicans Candida species in blood stream infections in a tertiary care hospital at New Delhi, India. Indian J Med Res. 136: 997-999. ##
Pacheco, M., Pisa, D., García-Gómez, P., Carrasco Llamas, L., Juarranz, A. (2007). Attachment and entry of Candida famata in monocytes and epithelial cells. Microsc Res Tech. 70: 975 - 986.##
Riley, C. B., Yovich, J. V., Robertson, J. P., O’hara, F. L. (1992) Fungal arthritis due to infection by Candida famata in a horse. Aust Vet J. 69: 65-66.##
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., Giannini, M. M. (2013) Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol. 62: 10-24.##
Schelenz, S. (2008) Management of candidiasis in the intensive care unit. J Antimicrob Chemother. 61: i31-i34.##
┼×eker, E. (2010) Identification of Candida species isolated from bovine mastitic milk and their in vitro hemolytic activity in Western Turkey. Mycopathologia. 169:  303-308.##