A Survey on Correlation Between Obesity and Hyperlipidemia in Companion Dogs of Ahvaz District

Document Type : Small Animal Health Management

Authors

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

2 Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

3 Graduated From the Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Abstract

BACKGROUND: In recent years, disorder in lipid metabolism has been increased markedly in companion animal’s population. Hyperlipidemia is a common sign of obesity in dogs, which is characterized by hypercholesterolemia or hypertriglycemia. OBJECTIVES:  The purpose of the present survey is to determine the effect of obesity on blood lipid profile changes (including triglyceride, total cholesterol, HDL-C and LDL-C) and comparing the decisive indicators of obesity in dogs in Ahvaz district. METHODS: Three groups of thirty dogs  referred to Veterinary Hospital of Ahvaz were studied between  2012-2014. The dogs in group A (control), had good body condition score (BCS= 4 to 5). The dogs were all thin (BCS= 1 to 3) in group B, and all obese in group C (BCS= 6 to 9). All of the studied dogs were selected from small breeds (Terrier, Spitz, Pekingese and Shih Tzu), of both sexes and ranging from 1 to 7 years old. Fasting blood samples were collected from all dogs and lipid profiles including serum triglycerides, total cholesterol, HDL and LDL were measured using commercial kits. RESULTS: Hyperlipidemia was confirmed in dogs of group A (normal) in 4 cases (13.33%), group B (thin) one case (3.33%), and group C (obese) in 19 cases (63.33%). Data analysis showed that there was a significant difference between group C (224.83±74.34) with groups A (149±39.66) and B (131.80±24.37) for triglyceride level (p<0.001), as well  a significant difference was seen between group C (229.40±60.36) with groups A (178.80±50.17) and B (151.47±23.45) and between group A with B for cholesterol level (p<0.05). The difference was significant for LDL-C between group C (67.10±22.83) with groups A (47.97±13.01) and B (43.07±13.08) (p<0.001), but there was no difference between various groups for HDL-C (p>0.05). The effects of age, gender and breed on the measured values did not show a significant difference between three groups (p>0.05). CONCLUSIONS: The present survey showed that there was a correlation between obesity and hyperlipidemia in dogs. Determination of body condition score (BCS) can be as a predictive agent in characterization of lipid profile status. Modification of diet and weight loss is necessary in obese dogs.

Keywords

References

Bailhache, E., Nguyen, P., Krempf, M., Siliart, B., Magot, T., Ouguerram, K. (2003) Lipoproteins abnormalities in obese insulin-resistant dogs. Metabolism. 52: 559-564.##
Barrie, J., Watson, T.D.G., Stear, M.J., Nash, A.S. (1993) Plasma cholesterol and lipoprotein concentrations in the dog: effect of age, breed, gender and endocrine disease. J Small Anim Pract. 34:507-512.##
Bauer, J.E. (2004) Lipoprotein-mediated transport of dietary and synthesized lipids and lipid abnormalities of dogs and cats. J Am Vet Med Assoc. 224: 668-675.##
Bauer, J.E. (2007) Responses of dogs to dietary omega-3 fatty acids. J Am Vet Med Assoc. 231: 1657-1661.##
Boland, L.L., Folsom, A.R., Rosamond, W.D. (2002) Hyperinsulinemia, dyslipidemia, and obesity as risk factors for hospitalized gallbladder disease: a prospective study. Ann Epidemiol. 12: 131-140.##
Briand, F., Magot, T., Krempf, M., Nguyen, P., Ouguerram, K. (2006) Effects of atorvastatin on high-density lipoprotein apolipoprotein A-I metabolism in dogs. Eur J Clin Invest. 36: 224-230.##
Brunetti, M.A., Nogueira, S., Cesar Sa, F., Peixotol, M., Vasconcellosl, R.S., Ferraudol, A.J., Carciofil, A.C. (2011) Correspondence between obesity and hyperlipidemia in dogs. Sci Rural. 41: 266-271. ##
Chikamune, T., Katamoto, H., Ohashi, F., Shimada, Y. (1995) Serum lipid and lipoprotein concentrations in obese dogs. J Vet Med Sci. 57: 595-598.##
Goncharov, N.P., Katsya, G.V., Chagina, N.A., Gooren, L.J. (2009) Testosterone and obesity in men under the age of 40 years. Andrologia. 41: 76-83.‏##
Courcier, E.A., Thomson, R.M., Mellor, D.J., Yam, P.S. (2010) An epidemiological study of environmental factors associated with canine obesity. J Small Anim Pract. 51: 362-367. ##
Cunningham, S.M., Rush, J.E., Freeman, L.M. (2013) Short-term effects of atorvastatin in normal dogs and dogs with congestive heart failure due to myxomatous mitral valve disease. J Vet Intern Med. 27: 985-989.##
Ettinger, S.J. (2005) The physical examination of the dog and cat. In: Textbook of Veterinary Internal Medicine. Ettinger, S.J. and Feldman, E.C.(eds.). (6th ed.) Elsevier Saunders. St. Louis, Missouri, USA. p. 2-9.##
Hajishafiha, M., Garehagaji, R., Salemi, S., SadeghAsadi, N. (2012) A Survey of Association among BMI with Semen Factors and Sex Hormones in Men. Med J Mashhad Univ Med Sci. 55: 102-109.##
Jeusette, I.C., Lhoest, E.T., Istasse, L.P., Diez, M.O. (2005) Influence of obesity on plasma lipid and lipoprotein concentrations in dogs. Am J Vet Res. 66: 81-86.##
Kawasumi, K., Kashiwado, N., Okada, Y., Sawamura, M., Sasaki, Y., Iwazaki, E., Mori, N., Yamamoto, I., Arai, T. (2014) Age effects on plasma cholesterol and triglyceride profiles and metabolite concentrations in dogs. BMC Vet Res. 10: 57.##
Kimiagar, M., Sohrab, G., Hemat, M., Golestan, B. (2011) The relationship between obesity and serum total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride level in men 18-34 years old living in district 6 of Tehran: comparison of BMI, waist and waist to hip ratio. Yafteh. 13: 56-63.##
Kubo, M. (2001) Clinical characteristics of hypertriglyceridemia-induced pancreatitis. Japan. J Clin Med. 59: 698-701.##
Lund, E.M., Armstrong, P.J., Kirk, C.A., Klausner, J.S. (2006) Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. Intern. J Appl Res Vet Med. 4: 177-186.##
Mao, J., Xia, Z., Chen, J., Yu, J. (2013) Prevalence and risk factors for canine obesity surveyed in veterinary practices in Beijing, China. Prev Vet Med. 112: 438-442.##
Mori, N., Lee, P., Kondo, K., Kido, T., Saito, T., Arai, T. (2011) Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs. Vet Res Commun. 35: 223-235.##
Newberne, P.M. (1996) Overnutrition on resistance of dogs to distemper virus. Fed Proc. 25: 1701-1710.##
Park, H.J., Lee, S.E., Kim, H.B., Isaacson, R.E., Seo, K.W., Song, K.H. (2015) Association of obesity with serum leptin, adiponectin, and serotonin and gut microflora in beagle dogs. J Vet Intern Med. 29: 43-50.##
Perez-Sanchez, A.P., Del-Angel-Caraza, J., Quijano-Hernandez, I.A., Barbosa-Mireles, M.A. (2015) Obesity-hypertension and its relation to other diseases in dogs. Vet Res Commun. 39: 45-51.##
Rim, S.J., Leong-Poi, H., Lindner, J.R., Wei, K., Fisher, N.G., Kaul, S. (2001) Decrease in coronary blood flow reserve during hyperlipidemia is secondary to an increase in blood viscosity. Circulation. 104: 2704-2709.##
Tilley, L.P., Smith, F.W.K. (2005) The 5-minute veterinary consult. (3rd ed.) Lippincott Williams and Wilkins, Maryland, USA. p. 1428.##
Verkest, K.R. (2014) Is the metabolic syndrome a useful clinical concept in dogs? A review of the evidence. Vet J. 199: 24-30. ##
Weintraub, H.S. (2014) Overview of prescription omega-3 fatty acid products for hypertriglyceridemia. Postgrad Med. 126: 7-18. ##
Xenoulis, P.G. (2014) The association between hyperlipidemia and gall bladder mucoceles in dogs. Vet J. 200: 353-354. ##
Xenoulis, P.G., Levinski, M.D., Suchodolski, J.S., Steiner, J.M. (2011) Association of hypertriglyceridemia with insulin resistance in healthy Miniature Schnauzers. J Am Vet Med Assoc. 238: 1011-1016.##
Xenoulis, P.G., Steiner, J.M. (2010) Lipid metabolism and hyperlipidemia in dogs. Vet J. 183: 12-21.
Xenoulis, P.G., Suchodolski, J.S., Levinski, M.D., Steiner, J.M. (2007) Investigation of hypertriglyceridemia in healthy Miniature Schnauzers. J Vet Intern Med. 21: 1224-1230.##
Journal of Veterinary Research
Volume 73, Issue 3
September 2018
Pages 335-344

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