عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Phenol is widely used in numerous non prescription products and the aim of present study was to investigate the dose- dependent effects of phenol on morphometrical and histometrical changes of kidney in an animal model. For this experiment, 60 adult female Balb/C mice were weighed, and categorrzed as one control and three experimental groups of 15 individuals each. Control group, received only distilled water without any additive materials and experimental groups received phenol (80, 180 and 320 mg/kg, respectively) by gastric tube for 10 days. After the 10th days, the mice were weiged and anesthetized by chloroform. Furthermore, after opening the abdomen, the length, diameter and width of right kidney were studied morphometrically. For histometrical studies, sections were prepared and stained with Hematoxylin and Eosin. weight, length and width of the kidney in the experimental groups showed significant increase compared to the control group. However, body weight, diameters of kidney and renal corpuscle did not show any difference among groups. In this respect, significant changes were shown for, the diameters of glomeruli, the lumen of distal and proximal convoluted tubules and tubular epithelial height in experimental groups compared to the control (p<0.05). Furthermore, the leukocytes infiltration in experimental groups showed more increase, compare to control. These results show morphometrical and histometrical changes of kidney after phenol administration.