تغییرات غلظت پلاسمایی هورمونهای تیروئیدی در گوسفندان تحت محدودیت انرژی و اثر تزریق وریدی لپتین بر آن

نویسندگان

1 گروه علوم دامی، دانشکده علوم زراعی و دامی، دانشگاه تهران، کرج

2 گروه زیست شناسی، دانشکده علوم پایه، دانشگاه شهید بهشتی تهران

3 گروه علوم درمانگاهی، دانشکده دامپزشکی دانشگاه تهران

4 دانش آموخته گروه علوم دامی، دانشکده کشاورزی دانشگاه تربیت مدرس تهران

چکیده

The aim of this study was to determine changes in the
concentration of leptin and thyroid hormone in
energyrestricted ewes and effect of leptin injection on
thyroid hormone level. In the first experiment, 28 ewes
were assigned to two groups(n=14). Ewes were fed by a
ration that provided 60% or 100% of maintenance energy
requirements during 71 days. Blood samples were
collected and body weight(BW) and body condition
score(BCS) were determined. In the second experiment, 6
energy-restricted ewes from the first experiment were
selected and assigned to two groups(n=3). Ewes were fed a
ration that provided 60% of maintenance energy
requirements and injected by 1 or 4 ?g leptin/Kg BW.
Blood samples were taken and BW and BCS were
determined. In the first experiment, concentrations of
leptin, T3 and T4, BW and BCS were decreased in
energyrestricted ewes(p<0.01). In the second experiment,
concentration of T3, T4 and leptin were increased by leptin
injection(p<0.01). The results suggested leptin injection
may restore thyroid hormone secretion to normal levels in
energy-restricted ewes.

کلیدواژه‌ها

عنوان مقاله [English]

CHANGES IN THE PLASMACONCENTRATIONS OF THYROID HORMONES IN ENERGYRESTRICTED EWES AND THE EFFECT OF INTRAVENOUS INJECTION OFLEPTIN ON THEIR LEVELS

نویسندگان [English]

  • armin towhidi 1
  • Homayoon Khazali 2
  • Amir Niasari Naslaji 3
  • Mahdi Zhandi 4
چکیده [English]

The aim of this study was to determine changes in the concentration of leptin and thyroid hormone in energyrestricted ewes and effect of leptin injection on
thyroid hormone level. In the first experiment, 28 ewes were assigned to two groups(n=14). Ewes were fed by a ration that provided 60% or 100% of maintenance energy requirements during 71 days. Blood samples were collected and body weight(BW) and body condition score(BCS) were determined. In the second experiment, 6 energy-restricted ewes from the first experiment were selected and assigned to two groups(n=3). Ewes were fed a ration that provided 60% of maintenance energy requirements and injected by 1 or 4 Kg leptin/Kg BW.Blood samples were taken and BW and BCS were determined. In the first experiment, concentrations of leptin, T3 and T4, BW and BCS were decreased in energyrestricted ewes(p<0.01). In the second experiment,concentration of T3, T4 and leptin were increased by leptin injection(p<0.01). The results suggested leptin injection may restore thyroid hormone secretion to normal levels in energy-restricted ewes.

کلیدواژه‌ها [English]

  • energy-restriction
  • Ewe
  • leptin
  • thyroid hormones
مجله تحقیقات دامپزشکی (Journal of Veterinary Research)
دوره 62، شماره 1
فروردین 1386
صفحه 15-20

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