ارزیابی شاخصههای متابولیکی سرم اسبهای دره شوری و ارتباط آنها با یکدیگر

نوع مقاله: بهداشت و بیماری های دام های بزرگ

نویسندگان

1 گروه علوم درمانگاهی، دانشکده دامپزشکی دانشگاه شیراز، شیراز، ایران

2 دامپزشک عمومی، بخش خصوصی

چکیده

زمینه مطالعه: نژادهای مختلف اسب دارای پروفایل متابولیکی مختص به خود می‌باشند که اطلاعات مربوط به این پروفایل نشان دهنده وضعیت سلامت آن هاست. هدف: هدف از انجام پژوهش حاضر، معرفی پروفایل متابولیک اسب‌های نژاد دره شوری و بررسی ارتباط آن‌ها با یکدیگر است. روش کار: نمونه‌های خون از 56 راس اسب دره شوری (5 تا 7 ساله) شامل26 راس مادیان غیر باردار و غیر شیرده و 30 راس نریان اخذ شد و در سرم آن‌ها گلوکز، انسولین، بتا‌هیدروکسی بوتیریک اسید، اسیدهای چرب غیر استریفه، کلسترول، تری گلیسرید و لیپوپروتئین‌های با چگالی بالا، کم و خیلی کم سنجیده شد. نتایج: غلظت سرمی بتا‌هیدروکسی بوتیریک اسید به طور معنی‌داری در نریان‌ها بالاتر از مادیان‌ها بود. سایر شاخصه‌های متابولیکی سرم فاقد تفاوت معنی‌دار بین دو گروه مورد مطالعه بودند. ارتباط منفی و غیر معنی‌داری بین انسولین و گلوکز در هر دو جنس از اسب‌های دره شوری مشاهده شد. انسولین رابطه‌ای منفی با کلسترول، تری گلیسرید و لیپوپروتئین‌های با چگالی بالا، کم و خیلی کم در دو گروه مورد مطالعه داشت. ارتباط منفی بین گلوکز با کلسترول، تری گلیسرید و لیپوپروتئین‌های با چگالی بالا، کم و خیلی کم در مادیان‌ها و نریان هامشاهده شد. نتیجهگیرینهایی: نتایج  مطالعه حاضر الگویی از مقادیر فیزیولوژیک پروفایل متابولیک نریان‌ها و مادیان‌های دره شوری غیر باردار را نشان داد که در نظر گرفتن این مقادیر، ممکن است دامپزشکان را در ارزیابی و شناسایی اختلالات متابولیکی اسب‌های دره شوری یاری دهد. هر چند که قرارگیری اسب‌های دره شوری در شرایط متفاوت فصلی، سنی، مدیریتی، تغذیه‌ای و فیزیولوژیک ممکن است این مقادیر را دستخوش تغییراتی نماید که در نظر داشتن شرایط مذکور در ارزیابی پروفایل متابولیک آن‌ها حائز اهمیت است.

کلیدواژه‌ها


عنوان مقاله [English]

Assessing the Serum Metabolic Biomarkers of Darehshori Horses and Their Relationships With Each Other

نویسندگان [English]

  • Aliasghar Chalmeh 1
  • Mehrdad Pourjafar 1
  • Saeid Nazifi 1
  • Seyed Mohammad Mahdi Heydari 1
  • Ali Alipour 1
  • Iman Saadat Akhtar 1
  • Mohammad Hosein Nooranizadeh 1
  • Vahidreza Khoshronejad 2
1 Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
2 D.V.M, Private Sector, Iran
چکیده [English]

BACKGROUND: Different breeds of horses have distinct and
specific metabolic profiles which reflect the health status of horses. OBJECTIVES:
The present study was performed to determine the circulating metabolic
biomarkers and their correlations in Darehshori horses. METHODS: Blood
samples were taken from 56 Darehshori horses (5 to 7 years old). They were
divided into 2 groups containing 26 non-pregnant and non-lactating mares and 30
stallions. Sera were separated and assayed for glucose, insulin,
beta-hydroxybutiric acid, non-esterified fatty acid, cholesterol, triglyceride
and high, low and very low density lipoproteins. RESULTS: Serum concentration
of beta-hydroxybutiric acid in stallions was significantly higher than in
mares. The remaining metabolic biomarkers showed no significant differences
between the two studied groups. There were negative and non- significant
correlations between insulin and glucose in both sexes. Insulin was negatively
correlated with cholesterol, triglyceride and high, low and very low density
lipoproteins in studied groups. The negative relationships were seen among
glucose and cholesterol, triglyceride and high, low and very low density
lipoproteins in mares and stallions. In both groups, non-esterified fatty acid
and beta-hydroxybutiric acid were negatively correlated with serum lipid
profile. CONCLUSIONS: The results of the present study provided a
general pattern for normal values of metabolic profile biomarkers in
non-pregnant mares and stallions of Darehshori horses. These values also help
veterinarians to diagnose metabolic abnormalities of this breed. However,
season, age, management, nutritional and different physiological states may
alter the values of these biomarkers and in interpreting the changes, these
conditions should be considered

کلیدواژه‌ها [English]

  • metabolic profile
  • base line level
  • Correlation
  • Darehshori horse
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