مقایسه تأثیر سنا و پلیاتیلن گلیکول در آمادهسازی روده به روش رادیوگرافی در سگ

نوع مقاله : تکنیک های تصویربرداری تشخیصی

نویسندگان

گروه علوم درمانگاهی، دانشگاه شهید چمران اهواز، اهواز، ایران

چکیده

زمینه مطالعه: آمادهسازی رودهها پیش از انجام تصویربرداری با اشعه ایکس برای نیل به یک تشخیص صحیح الزامی است. هدف: این مطالعه به منظور مقایسه اثرات سنا و پلیاتیلن گلیکول در آمادهسازی روده سگها پیش از رادیوگرافی از محوطه شکمی صورت گرفت. روشکار: شش قلاده سگ بالغ سالم از نژاد مخلوط، از هر دو جنس به فاصله سه هفته یکی از دو دوز g 4 و 8 به ازای هر کیلوگرم پلی اتیلن گلیکول و یا mg 20 به ازای هر کیلوگرم سنا را از طریق لوله معدی دریافت کردند. از حدود 12 ساعت قبل از تجویز داروها به سگها غذا داده نشد. رادیوگرافهای استاندارد توسط رادیولوژیست غیر مطلع از نوع رژیم آمادهسازی، بررسی و وجود مدفوع و گاز در کولون و راست روده، رادیواپسیته مدفوع و کیفیت رادیوگرافها جهت تشخیص، با یک معیار از صفر تا سه (صفر = نامناسب تا سه = عالی) امتیازبندی شد. نتایج: هر دو دوز پلیاتیلن گلیکول و سنا امتیاز آمادهسازی روده در سگها را به شکل معنیداری بهبود بخشیدند (05/0>p). هیچگونه اختلاف معنیداری بین سه گروه از نظر امتیاز آمادهسازی کولون، رادیواپسیته مدفوع و کیفیت رادیوگرافها وجود نداشت (05/0p). پلیاتیلن گلیکول با دوز g 8 به ازای هر کیلوگرم در مقایسه با دوز g 4 به ازای هر کیلوگرم به شکل معنیداری حضور مدفوع در راست روده را کاهش داد (05/0>p). همچنین از نظر بالینی و عوارض جانبی داروها، سگهای سه گروه تفاوتی نداشتند. نتیجهگیری نهایی: چنین میتوان نتیجه گرفت که استفاده از پلیاتیلن گلیکول با دوز g 8 به ازای هر کیلوگرم و سنا برای آمادهسازی روده در سگها بیخطر و مؤثر بوده و به خوبی توسط سگها تحمل میشود.

کلیدواژه‌ها


عنوان مقاله [English]

Comparison of effect of senna and polyethylene glycol on bowel preparation using radiography in dog

نویسندگان [English]

  • Reza Avizeh
  • Alireza Ghadiri
  • Amir Masoud Hajipour
Department of Clinical Sciences, Shahid Chamran Universityof Ahvaz, Ahvaz, Iran
چکیده [English]

BACKGROUND: A clean bowel preparation prior to X-ray examination is essential to obtain an accurate diagnosis. OBJECTIVES: This study was performed to compare the effect of senna and polyethylene glycol on the bowel preparation of dogs before abdominal radiography. METHODS: Six adult healthy mongrel dogs from each sex ranging in age from 18 to 30 months received either 4 or 8 g/kg polyethylene glycol or 20 mg/kg senna through an orogastric tube 3 weeks apart. Food was withheld approximately 12 hours prior to drug administration. Radiography was performed 12 hours after bowel preparation. Only water was given ad libitum to animals during the day before radiography. Radiologist who was unaware of the method of bowel preparation, reviewed the standard radiographs and graded the feces and gas in the colon and rectum, fecal radio-opacity and quality of radiographs on a scale of 0 to 3 (0=inadequate to 3=excellent). Dogs were observed for any drugs side effects up to two weeks after administration of the laxatives. RESULTS: The cleanliness scores of colon for the 4 and 8 g/kg polyethylene glycol and senna groups were similar, 2.17±0.41. Also, the cleanliness scores of rectum for the 4 and 8 g/kg polyethylene glycol and senna groups were 2.50±0.55, 1.83±0.75 and 2.50±0.55, respectively. Both polyethylene glycol dosages and senna significantly improve bowel cleansing score in dogs (p<0.05). There were no significant differences between the groups with respect to colon cleansing scores, fecal radio-opacity and quality of radiographs (p≥0.05). 8 mg/kg polyethylene glycol significantly reduces feces impaction in rectum versus 4 mg/kg (p<0.05). There were no clinical differences between the two groups for any of the side effects. CONCLUSIONS: It is concluded that 8 mg/kg polyethylene glycol and senna are safe and effective methods of colon cleansing, well tolerated by dogs.

کلیدواژه‌ها [English]

  • senna
  • polyethylene glycol
  • bowel preparation
  • Radiography
  • Dog
Amato, A., Radaelli, F., Paggi, S., Terruzzi, V. (2010) Half doses of PEG-ES and senna vs. highdose senna for bowel cleaning before colonoscopy: a randomized, investigator-blinded trial. Am J Gastroenterol. 105: 675-681.##
Beuers, U., Spengler, U., Pape, G.R. (1991) Hepatitis after chronic abuse of senna. Lancet. 337: 372-373.
Beubler, E., Juan, H. (1979) Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by the rat colon. J Pharm Pharmacol. 31: 681-685.##
Capasso, F., Izzo, A.A., Mascolo, N., Autore, G., Di Carlo, G. (1993) Effect of senna is not mediated by platelet-activating factor. Pharmacology, 47: 58-63.##
Frier, B.M., Scott, R.D. (1981) Hypertrophic osteoarthropathy and purgative abuse. Br Med J. 283: 439.##
Ghanbari, A., Abrahem Mosavi, M., Khaleghdoost, T, Yosephi, M., Atrkarroshan, Z. (2012) Patient compliance and bowel cleaning with routine bowel preparation method versus using oral sodium phosphate for colonoscopy. J Digest Endosc. 3: 77-81.##
Ghazikhanlou Sani, K., Jafari, M.R., Shams, S. (2010) A Comparison of the Efficacy, Adverse Effects, and Patient Compliance of the Sena-Graph®Syrup and Castor Oil Regimens for Bowel Preparation. Iran J Pharm Res. 9: 193-198.##
Hattori, M., Namba, T., Akao, T., Kobashi, K. (1988) Metabolism of sennosides by human intestinal bacteria. Pharmacology. 36: 172-179.##
Kobashi, K., Nishimura, T., Kusaka, M., Hattori, M., Namba, T. (1980) Metabolism of sennosides by human intestinal bacteria. Planta Med. 40: 225-236.##
Marks, G.B., Salome, C.M., Woolcock, A.J. (1991) Asthma and allergy associated with occupational exposure to ispaghula and senna products in a pharmaceutical work force. Am Rev Respir Dis. 144: 1065-1069.##
Mascolo, N., Autore, G., Izzo, A.A., Biondi, A., Caspasso, F. (1992) Effects of senna and its active compounds rhein and rhein-anthrone on PAF formation by rat colon. J Pharm Pharmacol. 44: 693-695.##
Mathias, J.R., Martin, J.L., Burns, T.W., Carlson, G.M., Shields, R.P. (1987) Ricinoleic acid effect on the electrical activity of the small intestine in rabbits. J Clin Invest. 61: 640-644.##
Nelson, D.E., Barkun, A.N., Block, K.P., Burdick, J.S., Ginsberg, G.G., Greenwald, D.A., Kelsey, P.B., Nakao, N.L., Slivka, A., Smith, P., Vakil, N. (2001) Technology Status Evaluation report. Colonoscopy preparations. Gastrointest Endosc. 54: 829-832.##
Radaelli, F., Meucci, G., Imperiali, G., Spinzi, G., Strocchi, E., Teruzzi V., Minoli, G. (2005) High-dose senna compared with conventional PEG-ES lavage as bowel preparation for elective colonoscopy: a prospective, randomized, investigator-blinded trial. Am J Gastroenterol. 100: 2674-2680.##
Richter, KP., Cleveland, MB. (1989) Comparison of an orally administered gastrointestinal lavage solution with traditional enema administration as preparation for colonoscopy in dogs. J Am Vet Med Assoc. 195(12): 1727-1731.##
Roohipour, M.R., Varasteh Kia, G.R., Tehrani Banihashemi, S.A., Moradi Lakeh, M. (2002) Comparison of two methods of bowel preparation: the efficacy of castor oil plus cotrimoxazole, metronidazole and ceftizoxime (ccmc), vs, poly ethylene glycol plus neomycin, erythromycin and cefamandol (pnec): a randomized double blinded study. Razi J Med Sci. 9: 349-355.##
Shavakhi, A., Kianinia, M., Torabi, G., Nemati, A., Saeidian, B., Hoseinzadeh, M., Madjlesi, F., Navaei, P., Rashidinejad, F., Minakari, M. (2011) High dose Senna or Poly Ethylene Glycol (PEG) for elective colonoscopy preparation: a prospective randomized investigator-blinded clinical trial. J Res Med Sci. 16: 149-155. ##
Staumont, G., Fioramonti, J., Frexinos, J., Bueno, L. (1988) Changes in colonic motility induced by sennosides in dogs: evidence of a prostaglandin mediation. Gut. 29: 1180-1187.##
Terry, N.A., Chen-Lim, M.L., Ely, E., Jatla, M., Ciavardone, D., Esch, S., Farace, L., Jannelli, F., Puma, A., Carlow, D., Mamula, P. (2013) Polythylene glycol powder solution versus senna for bowel preparation for colonoscopy in children. J Pediatr Gastroenterol Nutr. 56: 215-219.##
Torkan, S. Khamesipour, F. (2014) The Comparison of the Effects of Two Herbal Medicines, Namely Senna and Lactulose, on Induced Acute Constipation in Rabbits. Bull Environ Pharmacol Life Sci. 3: 1-6.##
Tunaru S., Althoff, T.F., Nusing, R.M., Diener, M., Offermanns, S. (2012) Castor oil induces laxation and uterus contraction via recinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci USA. 109: 9179-9184.##
Wexner, S.D., Beck, D.E., Baron, T.H., Fanelli, R.D., Hyman, N., Shen, B., Wasco, K.E. (2006) A consensus document on bowel preparation before colonoscopy; prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). Gastrointest Endosc. 63: 894-909.##