مقایسه تأثیر سنا و پلیاتیلن گلیکول در آمادهسازی روده به روش رادیوگرافی در سگ

نوع مقاله: تکنیک های تصویربرداری تشخیصی

نویسندگان

گروه علوم درمانگاهی، دانشگاه شهید چمران اهواز، اهواز، ایران

چکیده

زمینه مطالعه: آمادهسازی رودهها پیش از انجام تصویربرداری با اشعه ایکس برای نیل به یک تشخیص صحیح الزامی است. هدف: این مطالعه به منظور مقایسه اثرات سنا و پلیاتیلن گلیکول در آمادهسازی روده سگها پیش از رادیوگرافی از محوطه شکمی صورت گرفت. روشکار: شش قلاده سگ بالغ سالم از نژاد مخلوط، از هر دو جنس به فاصله سه هفته یکی از دو دوز g 4 و 8 به ازای هر کیلوگرم پلی اتیلن گلیکول و یا mg 20 به ازای هر کیلوگرم سنا را از طریق لوله معدی دریافت کردند. از حدود 12 ساعت قبل از تجویز داروها به سگها غذا داده نشد. رادیوگرافهای استاندارد توسط رادیولوژیست غیر مطلع از نوع رژیم آمادهسازی، بررسی و وجود مدفوع و گاز در کولون و راست روده، رادیواپسیته مدفوع و کیفیت رادیوگرافها جهت تشخیص، با یک معیار از صفر تا سه (صفر = نامناسب تا سه = عالی) امتیازبندی شد. نتایج: هر دو دوز پلیاتیلن گلیکول و سنا امتیاز آمادهسازی روده در سگها را به شکل معنیداری بهبود بخشیدند (05/0>p). هیچگونه اختلاف معنیداری بین سه گروه از نظر امتیاز آمادهسازی کولون، رادیواپسیته مدفوع و کیفیت رادیوگرافها وجود نداشت (05/0p). پلیاتیلن گلیکول با دوز g 8 به ازای هر کیلوگرم در مقایسه با دوز g 4 به ازای هر کیلوگرم به شکل معنیداری حضور مدفوع در راست روده را کاهش داد (05/0>p). همچنین از نظر بالینی و عوارض جانبی داروها، سگهای سه گروه تفاوتی نداشتند. نتیجهگیری نهایی: چنین میتوان نتیجه گرفت که استفاده از پلیاتیلن گلیکول با دوز g 8 به ازای هر کیلوگرم و سنا برای آمادهسازی روده در سگها بیخطر و مؤثر بوده و به خوبی توسط سگها تحمل میشود.

کلیدواژه‌ها


عنوان مقاله [English]

Comparison of effect of senna and polyethylene glycol on bowel preparation using radiography in dog

نویسندگان [English]

  • Reza Avizeh
  • Alireza Ghadiri
  • Amir Masoud Hajipour
Department of Clinical Sciences, Shahid Chamran Universityof Ahvaz, Ahvaz, Iran
چکیده [English]

BACKGROUND: A clean bowel preparation prior to X-ray examination is essential to obtain an accurate diagnosis. OBJECTIVES: This study was performed to compare the effect of senna and polyethylene glycol on the bowel preparation of dogs before abdominal radiography. METHODS: Six adult healthy mongrel dogs from each sex ranging in age from 18 to 30 months received either 4 or 8 g/kg polyethylene glycol or 20 mg/kg senna through an orogastric tube 3 weeks apart. Food was withheld approximately 12 hours prior to drug administration. Radiography was performed 12 hours after bowel preparation. Only water was given ad libitum to animals during the day before radiography. Radiologist who was unaware of the method of bowel preparation, reviewed the standard radiographs and graded the feces and gas in the colon and rectum, fecal radio-opacity and quality of radiographs on a scale of 0 to 3 (0=inadequate to 3=excellent). Dogs were observed for any drugs side effects up to two weeks after administration of the laxatives. RESULTS: The cleanliness scores of colon for the 4 and 8 g/kg polyethylene glycol and senna groups were similar, 2.17±0.41. Also, the cleanliness scores of rectum for the 4 and 8 g/kg polyethylene glycol and senna groups were 2.50±0.55, 1.83±0.75 and 2.50±0.55, respectively. Both polyethylene glycol dosages and senna significantly improve bowel cleansing score in dogs (p<0.05). There were no significant differences between the groups with respect to colon cleansing scores, fecal radio-opacity and quality of radiographs (p≥0.05). 8 mg/kg polyethylene glycol significantly reduces feces impaction in rectum versus 4 mg/kg (p<0.05). There were no clinical differences between the two groups for any of the side effects. CONCLUSIONS: It is concluded that 8 mg/kg polyethylene glycol and senna are safe and effective methods of colon cleansing, well tolerated by dogs.

کلیدواژه‌ها [English]

  • senna
  • polyethylene glycol
  • bowel preparation
  • Radiography
  • Dog
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